DAC Design Questions

Thu, 30 May 2024 08:21:35 +0000

Recent years witness the continuous clinical feasibility and increasing commercial value of antibody-drug conjugates (ADCs). As a result, many research institutions attempt to connect PROTAC with monoclonal antibody (mAb) by imitating the design principle of ADC to improve the delivery efficiency of PROTAC in vivo. This combination is called degrader-antibody conjugates (DACs), which can overcome the challenges brought by unconjugated PROTAC molecules, e.g. low efficiency due to its physicochemical properties and DMPK properties (especially the absence of E3 ligase CRBN), and non-specific targeting of PROTAC.