The Cutting-Edge of Targeted Protein Degradation: PROTACs, Linkers, and Molecular Glues

Thu, 16 Jan 2025 09:17:16 +0000

In recent years, the field of drug discovery has witnessed a transformative shift towards targeted protein degradation, a strategy that offers new avenues for treating diseases, particularly cancers and other conditions driven by aberrant protein activity. At the forefront of this innovative approach are Proteolysis Targeting Chimeras (PROTAC), their essential linkers, and the emerging concept of molecular glues. This article delves into the mechanisms, applications, and future potential of these groundbreaking technologies.